Linezolid intermediate
3-Fluoro-4-(4-Morpholinyl)-Benzeamine
CAS: 93246-53-8
Molecular Formula: C10H13FN2O
Linezolid intermediate - Names and Identifiers
| Name | 3-Fluoro-4-(4-Morpholinyl)-Benzeamine |
| Synonyms | AKOS B033533 TIMTEC-BB SBB010944 Linezolid intermediate 3-FLUORO-4-MORPHOLIN-ANILINE 3-Fluoro-4-morpholinoaniline 3-FLUORO-4-MORPHOLINOANILINE 3-Fluoro-4-morpholinyl aniline 3-FLUORO-4-MORPHOLINOPHENYLAMINE 3-fluoro-4-(morpholin-4-yl)aniline 3-Fluoro-4-(4-morpholinyl)-aniline 3-FLUORO-4-(4-MORPHOLINYL)-BENZEAMINE 3-Fluoro-4-morpholin-4-yl-phenylamine 3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE 3-Fluoro-4-(4-Morpholinyl)-Benzeamine 3-FLUORO-4-(4-MORPHOLINYL)-BENZENAMINE 3-fluoro-4-morpholin--4-yl-phenylamine |
| CAS | 93246-53-8 |
| EINECS | 676-003-1 |
| InChI | InChI=1/C10H13FN2O/c11-9-7-8(12)1-2-10(9)13-3-5-14-6-4-13/h1-2,7H,3-6,12H2 |
| InChIKey | FQGIBHQUVCGEAC-UHFFFAOYSA-N |
Linezolid intermediate - Physico-chemical Properties
| Molecular Formula | C10H13FN2O |
| Molar Mass | 196.22 |
| Density | 1.232±0.06 g/cm3(Predicted) |
| Melting Point | 121-123°C |
| Boling Point | 364.9±42.0 °C(Predicted) |
| Flash Point | 174.5°C |
| Solubility | Chloroform, Methanol |
| Vapor Presure | 1.63E-05mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | Off-White to Brown |
| pKa | 6.53±0.40(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.57 |
| MDL | MFCD02571270 |
Linezolid intermediate - Risk and Safety
| Hazard Class | IRRITANT |
Linezolid intermediate - Reference Information
| Introduction | The US FDA approved the marketing of linezolid in the US in April 2000, this is the first time that an oxazolidinone drug has been listed on the market, and it is also the first new antibacterial drug in 35 years. It is mainly used for Pneumonia, skin and skin tissue infections and vancomycin-resistant E. Faecalis infections. 3-fluoro-4-morpholinoaniline is an important intermediate for the synthesis of linezolid. |
| synthesis method | with 3, 4-difluoronitrobenzene and morpholine as raw materials, 3-fluoro-4-morpholinoaniline was synthesized by reduction of hydrazine hydrate catalyzed by ferric chloride hexahydrate. The main difference in the synthesis method is the reduction method used. Catalytic reduction using Pt/C, the reaction time is long and the product obtained is small. The new method uses ferric chloride hexahydrate to catalyze the reduction of hydrazine hydrate, which not only has high conversion rate, but also has simple treatment and short reaction time, and meets the requirements of industrial production [1]. The reaction formula for the synthesis of 3-fluoro-4-(4-morpholino)-aniline is shown below: |
Last Update：2024-04-09 19:05:15
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